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Qsymia is known that it was studied in two large trials involving a total of 3754 patients with a BMI greater than or equal to 27 kg / m2. Subjects in both studies had average baseline weights of 256 and 227 pounds, respectively, and average baseline waist circumferences of 47 inches and 45 inches, respectively. Patients were randomized into placebo, phentermine 3.75 mg / topiramate 23 mg (starting dose), phentermine 7.5 mg / topiramate 46 mg (recommended dose), or phentermine 15 mg / topiramate 92 mg (highest dose) ). In these trials, patients were advised to eat a balanced diet and reduce their calorie intake by 500 kcal per day. Qsymia know graph shows data for patients who completed treatment at each time point.